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Updated: Jul 15, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Catalytic asymmetric formation of beta-sultams
1Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, Hönggerberg HCI E 111, Zürich, Switzerland.
Abstract:
beta-Sultams, highly strained sulfonyl analogues of beta-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. The title compounds are practical precursors of highly enantioenriched biologically interesting beta-aminosulfonyl derivatives.
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