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Updated: Jul 15, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
Published on: September 5, 2025
Spatial location and its relevance for terminological inferences in bio-ontologies
Stefan Schulz1, Kornél Markó, Udo Hahn
1Medical Informatics Department, Freiburg University Hospital, Freiburg, Germany. stschulz@uni-freiburg.de
Background:
An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggregation and containment.
Results:
We demonstrate that the proposed formalism allows to deal consistently with "role propagation along non-taxonomic hierarchies", a problem which had repeatedly been identified as an intricate reasoning problem in biomedical ontologies.
Conclusion:
The proposed approach seems to be suitable for the redesign of compositional hierarchies in (bio)medical terminology systems which are embedded into the framework of the OBO (Open Biological Ontologies) Relation Ontology and are using knowledge representation languages developed by the Semantic Web community.
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