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Updated: Jul 15, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
First heart sound and opening snap in patients with mitral valve disease. Phonocardiographic and pathomorphologic
Abstract:
We investigated correlation between mitral valve morphology and first heart sound (S(1)) and opening snap (OS) amplitude. The analysis revealed negative correlation between the OS amplitude and the area of calcification and the mitral orifice area. We also found negative correlation between the S(1) intensity and the area of calcification.
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Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
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