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Updated: Jul 15, 2026
A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system
W F Abdo1, B P C van de Warrenburg, H P H Kremer
1Institute of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands. f.abdo@neuro.umcn.nl
Background:
Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile.
Methods:
We analyzed brain specific proteins and neurotransmitter metabolites in cerebrospinal fluid (CSF) of 26 patients with MSA-C and 19 with MSA-P.
Results:
No differences were found between MSA-C and MSA-P.
Conclusion:
Our results suggest that the clinical and in part pathological distinction between the two clinical MSA phenotypes is not reflected by the neurochemical composition of CSF.
