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Related Experiment Video

Updated: Jul 15, 2026

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
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Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

Saliva collection method affects predictability of serum cortisol.

Eva-Maria Poll1, Ilonka Kreitschmann-Andermahr, Yvonne Langejuergen

  • 1Department of Neurosurgery, RWTH-University Hospital Aachen, Germany. epoll@ukaachen.de

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 24, 2007
PubMed
Summary

Saliva cortisol measurement using Salivettes offers a reliable, non-invasive method for predicting serum cortisol levels. This method is more accurate than passive drool collection for assessing adrenocorticotropic function.

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Area of Science:

  • Endocrinology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Cortisol measurement is crucial for diagnosing adrenocorticotropic dysfunction and monitoring treatment.
  • Saliva offers a practical, non-invasive method for assessing glucocorticoid production.

Purpose of the Study:

  • To compare salivary cortisol collection using Salivette versus passive drool.
  • To correlate salivary cortisol with calculated free serum cortisol (FSC) and total serum cortisol (TSC).
  • To evaluate salivary cortisol as a predictor of serum cortisol levels.

Main Methods:

  • Saliva samples collected via Salivette and passive drool from 10 healthy volunteers over two days.
  • Simultaneous measurement of salivary cortisol, TSC, and calculation of FSC at six time points daily.

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Last Updated: Jul 15, 2026

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
08:25

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

Providing Meaningful Environmental Enrichment and Measuring Saliva Cortisol in Pigs Housed on Slatted Flooring
07:02

Providing Meaningful Environmental Enrichment and Measuring Saliva Cortisol in Pigs Housed on Slatted Flooring

Published on: September 30, 2019

  • Analysis of correlations between collection methods and serum cortisol levels.

    • Main Results:

    • Significant differences in salivary cortisol concentrations were observed based on collection method and time of day.
    • Salivette method showed stronger correlations with both TSC (r=0.813) and FSC (r=0.836) compared to passive drool.
    • Salivette provided a more accurate prediction of serum cortisol levels than passive drool collection.

    Conclusions:

    • Salivary cortisol measurement using Salivettes is a reliable method for predicting total and free serum cortisol.
    • The Salivette method is convenient for saliva collection, handling, and laboratory processing.