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Related Experiment Video

Updated: Jul 15, 2026

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

Investigating radial glia in vitro.

Steven M Pollard1, Luciano Conti

  • 1Wellcome Trust Centre for Stem Cell Research, University of Cambridge,Tennis Court Road, Cambridge CB2 1QR, United Kingdom. smp54@cam.ac.uk

Progress in Neurobiology
|April 24, 2007
PubMed
Summary

Radial glia, crucial for neuron development, actively divide and generate new neurons and glia. Understanding their behavior is key to CNS development and treating neurological disorders.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Radial glia guide neuronal migration during mammalian neurogenesis.
  • Previously viewed as static, radial glia are now known to actively divide in the developing central nervous system (CNS).
  • These cells produce both neurons and glia, with some forebrain radial glia potentially founding adult neural stem cells.

Purpose of the Study:

  • To review in vitro studies of radial glia.
  • To discuss the role of radial glia in CNS development and physiology.
  • To explore the potential of radial glia research for neurobiology.

Main Methods:

  • Review of in vitro investigations of isolated radial glia from fetal tissues.
  • Analysis of radial glia derived from embryonic stem (ES) cell differentiation.

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Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

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Study Glial Cell Heterogeneity Influence on Axon Growth Using a New Coculture Method
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  • Examination of studies utilizing expandable radial glia-like neural stem (NS) cell lines.

    • Main Results:

    • Radial glia exhibit active cell division, contributing to neurogenesis.
    • Disruption of radial glia function is linked to neurological disorders and tumorigenesis.
    • In vitro models provide insights into radial glia behavior and regulation.

    Conclusions:

    • Radial glia are dynamic, essential cells in CNS development.
    • In vitro studies and NS cell lines offer valuable tools for understanding radial glia.
    • Further research is crucial for advancing basic and applied neurobiology, potentially leading to treatments for neurological conditions.