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Published on: February 4, 2017
Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging
Bao Teng1, Yunpeng Bai, Yu Chang
1Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Bioorganic & Medicinal Chemistry Letters
|April 24, 2007
Abstract:
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.
