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Updated: Aug 19, 2026
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Electron microscopical investigation of rhinoscleroma (author's transl)]
Abstract:
A boy from Togo with a resistent Rhinoscleroma was observed. The specific granuloma was examinated by histological and electron microscopic methods. The plasma cells form fibrillary material or guttate Russel bodies in the rough endoplasmatic reticulum. The morphology of Mikulicz-cells and Klebsiella rhinoscleromatis is described. The cells are supposed to be (histiocytic) macrophages. The surface of the germs is coated with a fimbria-like radiate substance which in the vacuoles of the cells is crosslinked. This material could be the eliciting antigen for the formation of Russel bodies. These bodies then may represent immune substances bound within the cell.
Insights
This study examines a rare case of resistant Rhinoscleroma in a Togolese boy. Findings suggest that Russel bodies in plasma cells may represent immune substances bound within Mikulicz cells, triggered by Klebsiella rhinoscleromatis antigens.
Area of Science:
- Microbiology
- Immunology
- Pathology
Background:
- Rhinoscleroma is a chronic granulomatous disease caused by Klebsiella rhinoscleromatis.
- Resistant cases present diagnostic and therapeutic challenges.
Observation:
- A Togolese boy with resistant Rhinoscleroma was studied using histological and electron microscopy.
- The morphology of Mikulicz cells and Klebsiella rhinoscleromatis was detailed.
- Plasma cells exhibited fibrillary material and guttate Russel bodies within the rough endoplasmic reticulum.
Findings:
- Mikulicz cells are likely histiocytic macrophages.
- Klebsiella rhinoscleromatis surfaces possess a fimbria-like substance, crosslinked within vacuoles.
- This substance is hypothesized to be an antigen triggering Russel body formation.
Implications:
- Russel bodies may function as intracellular immune complexes.
- Understanding antigen-antibody interactions in Rhinoscleroma can inform treatment strategies.
- Further research into the immunopathology of resistant Rhinoscleroma is warranted.
