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Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

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A new paradigm for developmental biology.

John S Mattick¹

¹ARC Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia QLD 4072, Australia. j.mattick@imb.uq.edu.au

The Journal of Experimental Biology

|April 24, 2007

Summary

Complex organism development may be primarily directed by RNA regulatory networks, not just proteins. This suggests a hidden layer of RNA transactions controlling cellular differentiation and multicellular development.

Area of Science:

Developmental Biology
Genomics
Molecular Biology

Background:

Traditional models emphasize protein factors and cell signaling in organism development.
Recent evidence shows extensive genome transcription, suggesting non-protein-coding roles.

Purpose of the Study:

To propose a new model where RNA regulatory networks primarily drive epigenetic trajectories in development.
To highlight the significant, yet underappreciated, role of RNA in multicellular development.

Main Methods:

The study is primarily theoretical, proposing a new framework based on existing genomic and developmental data.
It synthesizes current understanding of genome transcription and regulatory networks.

Main Results:

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A significant portion of animal genomes is transcribed in a developmentally regulated manner.
This suggests a vast, hidden layer of RNA regulatory transactions.
RNA regulatory networks likely encode the primary information for multicellular development.

Conclusions:

Epigenetic trajectories of differentiation and development are predominantly programmed by feed-forward RNA regulatory networks.
Cell-cell signaling plays a crucial role in providing positional information and correcting errors within the RNA-directed program.
This RNA-centric view offers a new perspective on the fundamental mechanisms of development.