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Updated: Jul 15, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite
Toshiyuki Ikoma1, Toru Tonegawa, Hajime Watanaba
1National Institute for Materials Science, Biomaterials Center, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
Abstract:
Drug-supported spherical microparticles with below 3 microm in diameter of calcium carbonate (CC) nanocrystals were precipitated by a complex decomposition method from Na2CO3 and CaCl2 solutions with hydrocortisone phosphate (HyC). The HyC was completely incorporated into the microparticles and was adsorbed on the surface of nanocrystals. The crystal phases of vaterite and calcite were controlled by the addition of magnesium ions. Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp.
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