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Hexagonal surface gradient coil for localized MRS of the heart
A Jasinski1, P Kozlowski, A Urbanski
1Institute for Biological Sciences, National Research Council, Ottawa, Canada.
Magnetic Resonance in Medicine
|October 1, 1991
Summary
A novel surface gradient coil enables localized phosphorus-31 magnetic resonance spectroscopy of the heart. This technology differentiates normal from ischemic heart tissue in vivo, advancing cardiac diagnostics.
Area of Science:
- Biomedical Engineering
- Cardiovascular Imaging
- Magnetic Resonance Spectroscopy
Background:
- Localized magnetic resonance spectroscopy (MRS) is crucial for metabolic assessment.
- In vivo cardiac MRS presents technical challenges due to motion and tissue heterogeneity.
- Phosphorus-31 (31P) MRS provides vital metabolic information about cardiac energy status.
Purpose of the Study:
- To describe a novel surface gradient coil for in vivo cardiac 31P MRS.
- To evaluate the coil's performance using phantoms and animal models.
- To demonstrate the coil's utility in differentiating normal and ischemic heart tissue.
Main Methods:
- Design and implementation of a surface gradient coil for localized cardiac MRS.
- Acquisition of 31P spectra from phantoms and in vivo pig and dog hearts.
- Combination with an RF surface coil for transmural spectral acquisition.
Main Results:
- Successful generation of localized 31P spectra from phantoms and animal hearts.
- Demonstration of spectral differences between normal and ischemic myocardial tissue in dogs.
- Validation of the coil's capability for in vivo cardiac metabolic imaging.
Conclusions:
- The described surface gradient coil is effective for in vivo cardiac 31P MRS.
- This technique allows for non-invasive assessment of myocardial metabolism.
- The coil facilitates the detection of metabolic changes associated with cardiac ischemia.