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Related Experiment Video

Updated: Jul 15, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

Serotonin 5-HT(2C) receptors regulate anxiety-like behavior.

L K Heisler¹, L Zhou, P Bajwa

¹Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom. lkh30@medschl.cam.ac.uk

Genes, Brain, and Behavior

|April 25, 2007

Summary

The serotonin 5-HT(2C) receptor is crucial for anxiety behaviors. Mice lacking this receptor show reduced anxiety and less activation in key brain areas, revealing a new mechanism for anxiety regulation.

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Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

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Last Updated: Jul 15, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

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Published on: October 27, 2020

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

Area of Science:

Neuroscience
Psychiatry
Molecular Biology

Background:

Central serotonin (5-hydroxytryptamine, 5-HT) systems are implicated in anxiety disorders.
Anxiety disorders are highly prevalent psychiatric conditions requiring effective treatments.

Purpose of the Study:

Investigate the role of the serotonin 5-HT(2C) receptor (5-HT(2C)R) in anxiety-related behaviors.
Identify the neural substrates responsible for the anxiolytic effects observed in 5-HT(2C)R knockout mice.

Main Methods:

Utilized male 5-HT(2C)R knockout (KO) mice to study anxiety phenotypes.
Examined the activation of corticotropin-releasing hormone (CRH) neurons in the extended amygdala in response to anxiety stimuli.

Main Results:

5-HT(2C)R KO mice exhibited an anxiolytic phenotype.
These mice showed a selective blunting of CRH neuronal activation in the extended amygdala when exposed to anxiety-provoking stimuli.

Conclusions:

The 5-HT(2C)R plays a critical role in regulating anxiety-related behaviors.
Findings suggest a mechanism involving 5-HT(2C)Rs and extended amygdala CRH neurons in anxiety.
Provides insight into the neural circuitry of anxiety.