Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteins that associate with lamins: many faces, many functions.

Eric C Schirmer1, Roland Foisner

  • 1The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.

Experimental Cell Research
|April 25, 2007
PubMed
Summary

Lamin-associated polypeptides (LAPs) are crucial nuclear proteins involved in diverse cellular functions and human diseases. Understanding LAPs

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LAP2α drives breast tumorigenesis by mitigating replication stress.

Cell death & disease·2026
Same author

The unfolded protein response in progeria arteries originates from non-endothelial cell types.

Life science alliance·2025
Same author

Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.

Sub-cellular biochemistry·2025
Same author

Profibrotic Molecules Are Reduced in CRISPR-Edited Emery-Dreifuss Muscular Dystrophy Fibroblasts.

Cells·2025
Same author

Pairing Lamin B1-DamID and Immuno-3D-FISH to Resolve and Verify Peripheral Genome Organization of Adipogenesis.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.

Nature communications·2025

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Lamin-associated polypeptides (LAPs) are proteins associated with nuclear lamins, found in the inner nuclear membrane and nucleoplasm.
  • These proteins are implicated in various cellular processes, including gene expression, signaling pathways, and nuclear architecture.
  • Dysregulation of LAPs is linked to several human diseases, highlighting their critical roles.

Purpose of the Study:

  • To define Lamin-associated polypeptides (LAPs) and review their binding partners.
  • To elaborate on the functions of LAPs in nuclear organization, chromatin, gene expression, and signaling.
  • To summarize the current understanding of LAPs' involvement in human diseases.

Main Methods:

  • Literature review and synthesis of existing research on LAPs.
  • Analysis of protein-protein interactions and functional studies related to LAPs.
  • Compilation of data on the role of LAPs in various human pathologies.

Main Results:

  • LAPs are integral to nuclear structure and function, participating in diverse cellular mechanisms.
  • Key functions include sterol reduction, histone modification, transcriptional repression, and modulation of Smad and beta-catenin signaling.
  • LAPs often function within large multi-protein complexes, with some possessing enzymatic activities.

Conclusions:

  • LAPs are essential components of the nuclear environment with multifaceted roles.
  • Their involvement in fundamental cellular processes underscores their significance in maintaining cellular health.
  • Further research into LAPs and their associated complexes is crucial for understanding and potentially treating associated human diseases.

Related Experiment Videos