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Updated: Jan 11, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Age-related macular degeneration in very old individuals with family history
Asbjorg Geirsdottir1, Einar Stefansson, Fridbert Jonasson
1Department of Ophthalmology, Landspitali-University Hospital, Reykjavik, Iceland.
Purpose:
To study age-related macular degeneration (AMD) in old and very old individuals with family history of AMD to find the proportion of those with early and advanced AMD.
Design:
Retrospective cross-sectional cohort study of individuals with family history of AMD.
Methods:
Database of 897 AMD patients ages 75 to 102 years with family history of AMD was compiled. Color fundus photographs were graded in a masked fashion according to the International Classification of AMD.
Results:
With increasing age, a gradually larger proportion of participants had advanced AMD; 54% (469 of 863) of all those 75 years and older had advanced AMD, 64% (258 of 406) of all those 85 years and older, 74% (37 of 50) of all those 95 years and older, and all (eight of eight) 100 years and older had advanced AMD.
Conclusions:
All the centenarians in the present study had advanced AMD.
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