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Impact of celiac autoimmunity on children with type 1 diabetes

Jill H Simmons1, Georgeanna J Klingensmith, Kim McFann

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA. jill.simmons@uchsc.edu

The Journal of Pediatrics
|April 25, 2007
PubMed

Insights

Screening for celiac disease (CD) in children with type 1 diabetes (T1DM) identified altered body composition. Early CD diagnosis in T1DM children needs further study to confirm benefits.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Gastroenterology

Background:

  • Children with type 1 diabetes (T1DM) have an increased risk of celiac disease (CD).
  • The benefits of routine screening for CD in this population are not well-established.

Purpose of the Study:

  • To compare growth, bone density, and diabetes control in children with T1DM who screened positive for CD autoantibodies (TG+) versus those who screened negative (TG-).

Main Methods:

  • A comparative study involving 71 TG+ and 63 matched TG- children with T1DM.
  • Measurements included growth parameters (weight, BMI, midarm circumference), bone mineral density, and diabetes control metrics.

Main Results:

  • Children who screened TG+ showed significantly lower Z scores for weight, BMI, and midarm circumference compared to TG- children.
  • No significant differences were observed in bone mineral density or diabetes control between the groups.
  • Even when analyzing only TG+ children with biopsy-confirmed CD, BMI Z scores were lower than controls.

Conclusions:

  • Screening-identified CD in children with T1DM is associated with poorer body composition.
  • Early diagnosis and treatment benefits for CD in T1DM children require further investigation.
Abstract

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