Related Experiment Video
Updated: Jul 15, 2026
16:24
Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
INFO-RNA--a server for fast inverse RNA folding satisfying sequence constraints
1Albert-Ludwigs-University Freiburg, Institute of Computer Science, Bioinformatics Group, Georges-Koehler-Allee 106, 79110 Freiburg, Germany. abusch@informatik.uni-freiburg.de
Nucleic Acids Research
|April 25, 2007
Summary
INFO-RNA is a novel web server that automates RNA sequence design based on user-defined secondary structures and sequence constraints. This tool offers a faster and more efficient method for RNA sequence design for biologists.
Area of Science:
- Bioinformatics
- Computational Biology
- Molecular Biology
Background:
- Designing RNA sequences with specific secondary structures is crucial for various biological functions.
- Existing methods for RNA sequence design can be complex and time-consuming.
Purpose of the Study:
- To introduce INFO-RNA, a user-friendly web server for automated RNA sequence design.
- To enable the design of RNA sequences that conform to specified secondary structures and sequence constraints.
Main Methods:
- Development of a web server (INFO-RNA) for RNA sequence design.
- Implementation of algorithms to handle user-specified secondary structures.
- Inclusion of flexible constraint options, including nucleotide restrictions and allowed violations.
Main Results:
- INFO-RNA provides an intuitive and easy-to-use interface for biologists.
- The server rapidly designs RNA sequences, with most applications completing within seconds.
- INFO-RNA demonstrates superior speed and performance compared to existing RNA design tools.
Conclusions:
- INFO-RNA offers an efficient and automated solution for RNA sequence design.
- The tool simplifies the process of creating RNA sequences with desired structural properties.
- INFO-RNA is freely accessible, facilitating its adoption in biological research.
Related Concept Videos
01:29Protein Folding Quality Check in the RER
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
01:23RNA Structure
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
01:23RNA Structure
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
01:19RNA Structure
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
03:21RNA-seq
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
01:22Protein Folding
Overview