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Epithelial tight junctions, gene expression and nucleo-junctional interplay.

Karl Matter¹, Maria Susana Balda

¹Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK. k.matter@ucl.ac.uk

Journal of Cell Science

|April 25, 2007

Summary

Tight junctions, crucial for epithelial barriers, also regulate cell functions via nuclear signaling. Their altered expression in cancer suggests a tumor-suppressive role.

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