Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.

bioRxiv : the preprint server for biology·2026
Same author

Heterogeneity of White Matter Structure in the Human Brain.

Research square·2026
Same author

Heterogeneity of white-matter organization in the human brain.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: Foundation model of neural activity predicts response to new stimulus types.

Nature·2026
Same author

Motion perception with visual prostheses.

Progress in biomedical engineering (Bristol, England)·2026
Same author

Single-Cell Transcriptomic Analysis of Macaque LGN Neurons Reveals Novel Subpopulations.

Molecular neurobiology·2026

Related Experiment Video

Updated: Jul 15, 2026

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

Demonstration of artificial visual percepts generated through thalamic microstimulation.

John S Pezaris1, R Clay Reid

  • 1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. john_pezaris@hms.harvard.edu

Proceedings of the National Academy of Sciences of the United States of America
|April 25, 2007
PubMed
Summary

Electrical stimulation of the dorsal lateral geniculate nucleus (LGN) can create visual percepts in monkeys. This research supports the potential of microstimulation for developing visual prosthetics for the blind.

More Related Videos

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation
07:29

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Published on: April 1, 2010

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Related Experiment Videos

Last Updated: Jul 15, 2026

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation
07:29

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Published on: April 1, 2010

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Ophthalmology

Background:

  • Visual prosthetics aim to restore sight for individuals with blindness.
  • Electrical stimulation of visual pathways is a potential strategy for visual restoration.

Purpose of the Study:

  • To investigate if microstimulation of the dorsal lateral geniculate nucleus (LGN) can generate localized visual percepts.
  • To assess the feasibility of using LGN microstimulation for a visual prosthesis.

Main Methods:

  • An eye-movement task was employed with alert monkeys.
  • Targets were presented either optically or via microstimulation of the LGN.
  • Saccades (eye movements) were recorded and analyzed to compare responses to optical and electrical targets.

Main Results:

  • Saccades to electrically generated targets were comparable to those made to optical targets.
  • Gaze locations for electrical targets correlated with neuronal response maps at electrode sites.
  • Two distinct electrical targets could be independently generated using two electrodes.
  • Sequential saccade tasks confirmed that electrical targets are processed in visual spatial coordinates, not motor coordinates.

Conclusions:

  • Microstimulation of the dorsal LGN produces predictable visual percepts.
  • This technique shows promise as a component of a future visual prosthesis for the blind.