Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomere dynamics in macaques and humans.

Jeffrey P Gardner1, Masayuki Kimura, Weihang Chai

  • 1The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. gardner@umdnj.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|April 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.

bioRxiv : the preprint server for biology·2026
Same author

Quantile regression of the relationship between demographic factors and leukocyte telomere length, measured by Southern blot and qPCR.

GeroScience·2026
Same author

Detailed assessment of rare and common TERT variation in a family with a telomere biology disorder.

HGG advances·2025
Same author

REMOVED: Long Donor Leukocyte Telomeres Increase the Risk of Severe COVID-19 in Recipients of Allogeneic Hematopoietic Cell Transplant.

Transplantation and cellular therapy·2025
Same author

REMOVED: Leukocyte Telomere Shortening in Recipients after Hematopoietic Cell Transplant and Its Association with Factors That Affect Recipient Outcomes: An Analysis of BMT CTN Protocol 1202.

Transplantation and cellular therapy·2025
Same author

Long donor leukocyte telomeres raise risk of severe COVID-19 in recipients of allogeneic hematopoietic cell transplant.

Frontiers in immunology·2025

Telomere shortening with age occurs in macaques, similar to humans. This study in Macaca fascicularis provides insights into human aging and age-related diseases by examining telomere dynamics.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Comparative Biology

Background:

  • Telomere length shortens with age in human proliferating tissues, a process linked to age-related diseases.
  • Telomere attrition is a hallmark of aging, making nonhuman primates valuable models for human studies.
  • Understanding telomere dynamics in aging nonhuman primates can elucidate human aging mechanisms.

Purpose of the Study:

  • To investigate telomere length and attrition in Macaca fascicularis (macaque) tissues.
  • To compare telomere parameters between young and old macaques and with human tissues.
  • To establish the macaque as a model for human telomere biology and aging.

Main Methods:

  • Analysis of telomere length and subtelomeric segments in various tissues of young and old macaques.

Related Experiment Videos

  • Comparison of macaque telomere data with human tissue data.
  • Utilizing skeletal muscle telomere length as an internal reference to account for inter-animal variation.
  • Detection of telomerase activity in different macaque tissues.

    • Main Results:

    • Macaque telomeres were longer than human telomeres, partly due to longer subtelomeric segments.
    • Age-dependent telomere attrition was observed in macaque lung, pancreas, skin, and thyroid tissues.
    • Telomerase activity was detected in macaque spleen, thymus, digestive tract, and gonads, mirroring human patterns.
    • Skeletal muscle telomere length remained unchanged with age, serving as a reliable reference.

    Conclusions:

    • The macaque serves as a relevant model for studying human telomere biology and aging.
    • Factors influencing telomere attrition and aging in humans appear to be conserved in macaques.
    • Comparative studies of telomere dynamics can enhance our understanding of aging processes across species.