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Association between vitamin D status and physical performance: the InCHIANTI study
Denise K Houston1, Matteo Cesari, Luigi Ferrucci
1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. dhouston@wfubmc.edu
Summary
Low vitamin D levels are linked to poorer physical performance in older adults. Maintaining adequate vitamin D is crucial for preserving strength and mobility in seniors.
Area of Science:
- Gerontology
- Nutritional Science
- Musculoskeletal Health
Background:
- Vitamin D status is a potential factor influencing musculoskeletal function.
- Research has explored the relationship between vitamin D levels and physical capabilities in aging populations.
Purpose of the Study:
- To investigate the association between vitamin D status and physical performance in older adults.
- To analyze the correlation between serum 25-hydroxyvitamin D (25OHD) and parathyroid hormone (PTH) with physical function metrics.
Main Methods:
- Utilized data from 976 individuals aged 65+ from the InCHIANTI study.
- Assessed physical performance via the Short Physical Performance Battery (SPPB) and handgrip strength.
- Employed multiple linear regression, adjusting for numerous confounding variables.
Main Results:
- Significant associations were found between vitamin D levels and SPPB scores in men, and handgrip strength in both men and women.
- Vitamin D deficiency (serum 25OHD < 25.0 nmol/L) correlated with lower SPPB scores.
- Vitamin D insufficiency (serum 25OHD < 50.0 nmol/L) correlated with lower handgrip strength.
Conclusions:
- Vitamin D status demonstrates an inverse relationship with diminished physical performance.
- High prevalence of vitamin D deficiency in older adults necessitates further research into its impact on physical function.
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