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Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
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Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

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Bone density and breaking strength in UK raptors exposed to second generation anticoagulant rodenticides

L D Knopper1, P Mineau, L A Walker

  • 1Environmental and Occupational Health Sciences, Jacques Whitford, 200-2781 Lancaster Drive, K1B 1A7 Ottawa, Canada. loren.knopper@jacqueswhitford.com

Bulletin of Environmental Contamination and Toxicology
|April 25, 2007
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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