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Updated: Jul 15, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?
Michal Schwarz1, Miguel A Andrade-Navarro, Atan Gross
1Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.
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