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Decline in breast cancer incidence after decrease in utilisation of hormone replacement therapy.

Alexander Katalinic1, Rajesh Rawal

  • 1Institute of Cancer Epidemiology, University of Lübeck, Beckergrube 43-47, 23552, Lubeck, Germany. alexander.katalinic@krebsregister-sh.de

Breast Cancer Research and Treatment
|April 25, 2007
PubMed
Summary
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Reduced hormone replacement therapy (HRT) use correlates with declining breast cancer incidence in women over 50. This population-based study in Germany observed a significant link between decreased HRT utilization and lower breast cancer rates.

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Hormone replacement therapy (HRT) use has declined due to its association with increased breast cancer risk.
  • Early indications suggest a potential decrease in breast cancer incidence following reduced HRT utilization.

Purpose of the Study:

  • To investigate the relationship between decreasing HRT use and breast cancer incidence in Schleswig-Holstein, Germany.
  • To provide population-based evidence for trends in breast cancer incidence and HRT utilization.

Main Methods:

  • Utilized breast cancer incidence data from the Schleswig-Holstein cancer registry.
  • Extracted HRT utilization data from a cohort of 102,000 women (2001-2005).
  • Measured annual percentage changes using linear regression analysis.

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Main Results:

  • A consistent decline in HRT utilization was observed across all age groups (2001-2005).
  • Breast cancer incidence decreased in women over 50 and overall, but not in those under 50.
  • A significant correlation was found between decreased HRT use and declining breast cancer incidence, with a two-year lag.

Conclusions:

  • The decline in breast cancer incidence appears linked to reduced HRT usage.
  • A notable shift in the age-incidence relationship for breast cancer has occurred.
  • Continued monitoring of HRT use and other factors is crucial for understanding future breast cancer trends.