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[Structure and function of receptors for C3 cleavage fragments]
E Fischer1, C Couturier, L Weiss
1INSERM U 28, Hôpital Broussais, Paris.
Nephrologie
|January 1, 1991
Summary
This review details complement receptors CR1, CR2, and CR3, which bind C3 fragments and are crucial for immune responses like phagocytosis and immune complex transport.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Context:
- Complement activation generates fragments that interact with cellular receptors.
- Understanding these interactions is key to deciphering immune responses.
- Specific receptors bind to C3 cleavage fragments, mediating biological effects.
Purpose:
- To review the structure and function of receptors for C3 cleavage fragments.
- To highlight the cloned genes encoding these receptors.
- To discuss their cellular distribution and roles in biological processes.
Summary:
- CR1, CR2, and CR3 are integral transmembrane glycoproteins.
- These receptors bind human C3b, C3dg/C3d, and C3bi fragments, respectively.
- They are widely distributed on cells and involved in immune complex transport, phagocytosis, and immune response regulation.
Impact:
- Provides a comprehensive overview of C3 fragment receptors.
- Highlights the significance of these receptors in various physiological and pathological conditions.
- Informs research on immune regulation and potential therapeutic targets.