Related Experiment Video
Updated: Jul 15, 2026

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
Physiological and pathological implications of laminins: from the gene to the protein
María-Carolina Páez1, María-Julieta González, Norma C Serrano
1Biomedical Research Center, School of Medicine at Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
Abstract:
The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren's syndrome (SS) are also discussed.
Related Concept Videos
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can exist in...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Basal Lamina are the Specialized Form of ECM
Proteins...
Cytoskeletal Linker Proteins - Plakins
Intracellular Signaling Affects Focal Adhesions
Some...

