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Updated: Jul 15, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Allograft inflammatory factor-1 and its immune regulation
Guangwei Liu1, Haixia Ma, Lingling Jiang
1Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China.
Autoimmunity
|April 25, 2007
Summary
Allograft inflammatory factor-1 (AIF-1) is an immune regulatory protein. This review covers AIF-1 family proteins, highlighting their role in inflammation and autoimmune diseases.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Allograft inflammatory factor-1 (AIF-1) is an interferon-gamma (IFN-gamma) inducible protein.
- AIF-1 is expressed in monocytes and macrophages, and its expression is augmented by cytokines like IFN-gamma.
- AIF-1 is implicated in inflammatory responses, allograft rejection, and macrophage activation.
Purpose of the Study:
- To review the genomic and functional characteristics of AIF-1 family proteins.
- To explore the immune regulatory effects of AIF-1.
- To discuss the potential role of AIF-1 in autoimmune diseases.
Main Methods:
- Literature review of AIF-1 family proteins.
- Analysis of genomic and functional characteristics.
- Examination of immune regulatory effects and roles in autoimmunity.
Main Results:
- AIF-1, also known as ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain, is encoded in the HLA class III region.
- AIF-1 expression is primarily in the monocyte/macrophage lineage.
- AIF-1 is expressed in macrophages and microglial cells in models of autoimmune diseases, suggesting a role in autoimmunity.
Conclusions:
- AIF-1 plays a significant role in immune regulation.
- AIF-1 is involved in both inflammatory responses and autoimmune diseases.
- Further research into AIF-1 family proteins is warranted to understand their full impact on immunity.
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