Lack of association between pseudoexfoliation syndrome and manganese superoxide dismutase polymorphism
Huseyin Yuce1, Ibrahim F Hepsen, Ibrahim Tekedereli
1Department of Medical Biology and Genetics, Firat University Medical Faculty, Elazig, Turkey. hyuce@firat.edu.tr
Purpose:
The aim of this clinical study was to investigate the possible association between manganese superoxide dismutase (Mn-SOD) enzyme polymorphism in the mitochondrial targeting sequence and pseudoexfoliation syndrome.
Methods:
Ala (GTT) or Val (GCT) polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with restriction enzyme NgoM IV.
Results:
The frequencies of Ala-9 and Val-9 variants and genotypes of Mn-SOD were similar in the controls and pseudoexfoliation syndrome patients.
Conclusions:
These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with pseudoexfoliation syndrome.
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