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Related Experiment Video

Updated: Jul 15, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Apolipoprotein E alleles and sensorineural hearing loss.

Gwen O'Grady¹, Abee L Boyles, Marcy Speer

¹Department of Surgery (Division of Speech Pathology & Audiology), Duke University Medical Center, Durham, NC 27710, USA.

International Journal of Audiology

|April 25, 2007

Summary

The APOE epsilon 4 allele was less common in adults with sensorineural hearing loss (SNHL) than in the general population. This study found no link between the APOE epsilon 4 allele and SNHL severity.

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Area of Science:

Genetics
Audiology
Neurology

Background:

Sensorineural hearing loss (SNHL) is a common condition affecting adults.
The apolipoprotein E (APOE) gene, particularly the epsilon 4 allele, has been implicated in various neurological conditions.
The role of APOE alleles in nonsyndromic SNHL remains unclear.

Purpose of the Study:

To investigate the association between APOE alleles and nonsyndromic, adult-onset sensorineural hearing loss.
To compare APOE allele frequencies in SNHL patients with those in the general population.
To explore potential correlations between APOE epsilon 4 allele presence and the severity of hearing loss or word recognition impairment.

Main Methods:

Genotyping for APOE alleles was performed on DNA from 89 adult SNHL subjects.
APOE allele frequencies in the study cohort were compared to general population data.
Subjects were stratified by hearing loss severity and word recognition impairment severity for further analysis.

Main Results:

The APOE epsilon 4 allele was found to be under-represented in the study sample of SNHL patients compared to the general population.
No significant association was detected between the APOE epsilon 4 allele and the severity of hearing loss.
Similarly, no relationship was observed between the APOE epsilon 4 allele and the severity of word recognition impairment.

Conclusions:

The APOE epsilon 4 allele appears to be less prevalent in adults with nonsyndromic SNHL.
Current findings do not support a direct link between APOE epsilon 4 and SNHL severity.
Future research should consider population-based, longitudinal designs or younger cohorts to further elucidate the role of APOE in SNHL.