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Purification and Expansion of Mouse Invariant Natural Killer T Cells for in vitro and in vivo Studies
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Therapeutic potential of CD1d-restricted invariant natural killer T cell-based treatment for autoimmune diseases

Sachiko Miyake1, Takashi Yamamura

  • 1Department of Immunology, National Institute of Neuroscience, Kodaira, Tokyo, Japan.

International Reviews of Immunology
|April 25, 2007
PubMed

CD1d-restricted invariant natural killer T (iNKT) cells are a unique subset of T cells that recognize glycolipid antigens presented by the CD1d molecule. iNKT cells participate in various kinds of immunoregulation due to a potent ability to produce a variety of cytokines. Recent advances in studies of novel synthetic glycolipid ligands has led to new strategies to manipulate the pleiotropic functions of iNKT cells. The molecular mechanism of selective cytokine production by glycolipid ligands will be discussed. We will also focus on the possible therapeutic application of such ligands for the clinical treatment of various autoimmune diseases.

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