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Related Experiment Videos

Vesicular phospholipid gels: a technology platform.

Martin Brandl1

  • 1Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmacy, University of Tromsø, Breivika, Tromsø, Norway. martinb@farmasi.uit.no

Journal of Liposome Research
|April 25, 2007
PubMed
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Vesicular phospholipid gels (VPGs) offer stable drug delivery for various compounds, acting as depot implants or easily converting into liposomes. These gels also serve as effective models for screening oral drug permeability, correlating well with in vivo absorption.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Vesicular phospholipid gels (VPGs) are semi-solid phospholipid dispersions with unique vesicular morphology.
  • They possess aqueous compartments internally and externally, enabling encapsulation of hydrophilic, amphiphilic, and lipophilic drugs.

Purpose of the Study:

  • To explore the potential of VPGs as versatile drug delivery systems.
  • To evaluate VPGs for controlled drug release, depot implant applications, and conversion into small unilamellar vesicles (SUVs).
  • To assess VPGs as a model for screening oral drug permeability.

Main Methods:

  • VPGs were formulated to encapsulate various drug types.
  • Drug-loaded VPGs were tested in human xenografts with cytostatic drugs.

Related Experiment Videos

  • VPGs were adapted onto filter supports to create a diffusion barrier model.
  • The model was used to screen the oral permeability of 21 drug compounds.

    • Main Results:

    • VPGs demonstrated stable drug loading without concentration gradients.
    • Successful in vivo testing of VPG-cytostatic drug formulations in human xenografts, showing protection from inactivation and passive targeting to tumors.
    • VPGs, when blended with aqueous media, formed SUVs with high encapsulation efficiencies.
    • The VPG diffusion barrier model showed permeability values that correlated well with human in vivo absorption.

    Conclusions:

    • VPGs are effective drug delivery systems offering stable loading, controlled release, and potential for depot implants.
    • VPGs facilitate passive drug targeting to solid tumors.
    • The VPG-based diffusion barrier model is a valuable tool for rapid screening of oral drug permeability and predicting in vivo absorption.