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Related Experiment Videos

Microsatellite instability in long-standing ulcerative colitis.

Tone Løvig1, Solveig Norheim Andersen, Ole Petter Clausen

  • 1Institute of Forensic Medicine, Department of Pathology, Akershus University Hospital HF, Lørenskog, Norway. tone.lovig@labmed.uio.no

Scandinavian Journal of Gastroenterology
|April 25, 2007
PubMed
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Microsatellite instability (MSI) is rare in ulcerative colitis (UC) related neoplasia and non-neoplastic lesions. This study found MSI does not contribute to the development of dysplasia in long-standing UC.

Area of Science:

  • Gastroenterology
  • Oncology
  • Molecular Biology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory condition linked to an increased risk of colorectal cancer.
  • Genetic alterations are observed in UC-associated dysplasia and cancer.
  • Previous studies on microsatellite instability (MSI) in UC have yielded conflicting results.

Purpose of the Study:

  • To analyze a large cohort of well-characterized UC tissue for MSI.
  • To clarify the significance of MSI in long-standing UC and UC-related neoplasia.

Main Methods:

  • Analysis of 159 microdissected lesions and 165 adjacent mucosa samples from 33 UC patients.
  • Utilized five standard National Cancer Institute recommended MSI markers (D2S123, D5S346, D17S250, BAT-25, BAT-26).

Related Experiment Videos

  • Additionally, a mini-satellite marker at the D1S7 locus was used for 12 patients.

    • Main Results:

    • High-level MSI (MSI-H) was identified in one case (3.6%) of villous adenoma with high-grade dysplasia.
    • This single instance was located in the right side of the colon.
    • No other investigated lesions exhibited MSI using the standard markers or the D1S7 locus.

    Conclusions:

    • MSI appears to be infrequent in both neoplastic and non-neoplastic lesions associated with UC.
    • The findings suggest MSI does not play a significant role in the development of dysplasia in UC.