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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

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Related Experiment Video

Updated: Jul 15, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Common variable immune deficiency and lung transplantation.

Christopher M Burton1, Nils Milman, Claus B Andersen

  • 1Division of Lung Transplantation, Department of Medicine B, University of Copenhagen, Denmark. cmburton@doctors.net.uk

Scandinavian Journal of Infectious Diseases
|April 25, 2007
PubMed
Summary

Lung transplantation in common variable immune deficiency (CVID) patients presents significant challenges. This case highlights severe post-operative complications including rejection and aspergillosis, underscoring the need for specialized care and registries.

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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

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Published on: November 10, 2023

Area of Science:

  • Immunology
  • Pulmonology
  • Transplantation Medicine

Background:

  • Common Variable Immune Deficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
  • Lung transplantation is a potential treatment for end-stage lung disease in CVID patients, but carries inherent risks.
  • This report details a CVID patient undergoing single lung transplantation.

Observation:

  • The patient experienced severe acute cellular rejection and organizing pneumonia post-transplantation.
  • Recurrent Aspergillus fumigatus infection was identified 18 months post-transplant despite antifungal treatment.
  • The patient succumbed to complications 46 months after the procedure.

Findings:

  • CVID patients may face complex post-operative courses after solid-organ transplantation.
  • Immunosuppressive regimens require careful management in immunocompromised transplant recipients.
  • Fungal infections, such as aspergillosis, pose a significant threat in this population.

Implications:

  • Transplantation in CVID patients necessitates multidisciplinary management and vigilant monitoring.
  • There is a critical need for international registries to track outcomes of solid-organ transplantation in rare conditions like CVID.
  • Further research is warranted to optimize peri-operative care and long-term management strategies for CVID patients undergoing transplantation.