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Published on: October 12, 2017
Hypercalciuria in pediatric patients with ureteropelvic junction obstruction is of genetic origin
Víctor García-Nieto1, Juan F Navarro, Ma Isabel Luis-Yanes
1Pediatric Nephrology Unit, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, Spain. vgarcia@comtf.es
Insights
Children with ureteropelvic junction obstruction (UPJO) show a high prevalence of hypercalciuria. This metabolic abnormality, often linked to urolithiasis, appears to be inherited as an autosomal dominant trait within families.
Area of Science:
- Pediatric Nephrology
- Urology
- Medical Genetics
Background:
- Genitourinary tract malformations are linked to urolithiasis.
- Hypercalciuria has been observed in children with ureteropelvic junction obstruction (UPJO), but its cause is unclear.
Purpose of the Study:
- To determine the prevalence of hypercalciuria in children with UPJO.
- To investigate the occurrence of hypercalciuria and urolithiasis in family members of these children.
Main Methods:
- A study involving 27 children diagnosed with UPJO and their parents.
- Assessment of hypercalciuria and urolithiasis prevalence within the studied cohort and their families.
Main Results:
- Hypercalciuria was detected in 63% of pediatric UPJO patients.
- A significant familial history of urolithiasis was noted in 88% of children with hypercalciuria and 70% without.
- Urolithiasis and hypercalciuria prevalence were not gender-dependent.
Conclusions:
- Urolithiasis is associated with hypercalciuria in pediatric UPJO patients.
- The prevalence of hypercalciuria and familial urolithiasis is higher in UPJO patients compared to the general population.
- Hypercalciuria in this context appears to be inherited in an autosomal dominant pattern.
Objective:
Genitourinary tract malformations are associated with urolithiasis. Hypercalciuria has been described in children with ureteropelvic junction obstruction (UPJO), although the etiology of this metabolic abnormality remains unknown. This study was conducted to find out whether children with UPJO have a higher prevalence of hypercalciuria and whether their family members are affected by hypercalciuria and/or urolithiasis.
Material And Methods:
We studied the prevalence of hypercalciuria and urolithiasis in 27 children (14 males, 13 females) with UPJO and their parents.
Results:
One patient had a history of renal colic, whereas imaging studies showed macroscopic renal lithiasis in two patients and calyceal microlithiasis in four. Hypercalciuria was found in 17/27 children (63%), 15 of whom (88%) had a familial history of urolithiasis: seven families in first-degree relatives, six in second-degree relatives and two in other relatives. Concerning the 10 children without hypercalciuria, seven of them (70%) had a family history of urolithiasis: four in first-degree relatives and three in second-degree relatives. The prevalences of both urolithiasis and hypercalciuria were not influenced by gender.
Conclusions:
Urolithiasis is associated with hypercalciuria in patients with UPJO. In accordance with previous data, our results show that the prevalence of hypercalciuria is greater in pediatric patients with UPJO than in the general population. Likewise, the prevalence of urolithiasis in the families of these children is also higher than that in the general population. Hypercalciuria was inherited as an autosomal dominant trait.
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