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Updated: Jul 15, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

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Published on: December 1, 2013

Urothelial adenocarcinoma in a non-functioning bladder.

Muhammad Hassan Khan¹, Mahanta Devan Dooldeniya, Nick A Shaikh

¹Department of Urology, Airedale General Hospital, Keighley, UK. drtahirkheli@hotmail.com

Scandinavian Journal of Urology and Nephrology

|April 25, 2007

Summary

Urinary diversion for incontinence can lead to bladder cancer, even in non-functioning bladders. This case highlights the risk of silent tumors developing years after the procedure.

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Area of Science:

Urology
Oncology

Background:

Urinary diversion is a standard procedure for managing refractory long-term incontinence, particularly in young patients with neurogenic bladders.
In these cases, the bladder is disconnected and remains in situ, often becoming non-functioning.

Observation:

A rare case of adenocarcinoma of the bladder was diagnosed 31 years after a urinary diversion procedure.
The patient had a neurogenic bladder and underwent bladder disconnection and in situ preservation.

Findings:

This case raises concerns about the potential for developing silent bladder tumors in non-functioning bladders following urinary diversion.
The long latency period suggests a need for long-term surveillance.

Implications:

Patients undergoing urinary diversion may be at risk for delayed bladder cancer development.
Further research is warranted to assess the incidence and optimal screening strategies for bladder neoplasms in these patients.