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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

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Published on: July 6, 2017

Expression of TFF3 during multistep colon carcinogenesis.

R John¹, N M El-Rouby, C Tomasetto

¹Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, UAE.

Histology and Histopathology

|April 25, 2007

Summary

Trefoil Factor 3 (TFF3) expression decreases in early colon cancer stages but increases in later stages, suggesting a protective role against colon carcinogenesis. Its down-regulation in invasive cancers indicates a complex involvement in tumor progression.

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In vitro Organoid Culture of Primary Mouse Colon Tumors

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Published on: May 17, 2013

Area of Science:

Gastroenterology
Oncology
Molecular Biology

Background:

Colon cancer pathogenesis involves genetic alterations.
TFF3 is linked to mucosal protection and cancer cell aggressiveness.

Purpose of the Study:

Analyze TFF3 expression during human colon cancer development.
Correlate TFF3 levels with cell proliferation and cancer progression.

Main Methods:

Immunohistochemistry for TFF3 expression.
PCNA-labeling for cell proliferation.
Analysis of tissues from colitis to adenocarcinoma.

Main Results:

TFF3 down-regulated in adenomatous polyposis.
TFF3 expression returned to control levels in adenomas.
TFF3 remained high in mucoid/adenocarcinomas.
Significant TFF3 down-regulation observed in invasive cancers.

Conclusions:

TFF3 expression changes inversely with cell proliferation.
TFF3 may play a protective role in colon carcinogenesis.
TFF3's role is complex, decreasing in invasive stages.