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Related Experiment Videos

Microenvironmental pH modulation in solid dosage forms.

Sherif I Farag Badawy1, Munir A Hussain

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, USA.

Journal of Pharmaceutical Sciences
|April 25, 2007
PubMed
Summary
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Modulating the microenvironmental pH of solid dosage forms significantly impacts drug stability and dissolution. Careful selection of pH modifiers or counter ions can optimize drug performance and enhance shelf-life.

Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry

Background:

  • Microenvironmental pH significantly affects solid dosage form stability and dissolution.
  • Existing pH measurement techniques have limitations but confirm pH's impact.

Purpose of the Study:

  • To review the impact of microenvironmental pH on solid dosage form performance.
  • To discuss strategies for modulating microenvironmental pH to enhance drug stability and control dissolution.

Main Methods:

  • Literature review of studies on microenvironmental pH measurement and modulation.
  • Analysis of pH-dependent stability and dissolution profiles of various drug compounds.

Main Results:

  • Microenvironmental pH directly influences degradation kinetics and profiles of pH-sensitive compounds.

Related Experiment Videos

  • pH modifiers can enhance solid dosage form stability and control dissolution rates.
  • Optimized salt forms can intrinsically provide a favorable microenvironmental pH.

    • Conclusions:

    • Microenvironmental pH modulation is a key strategy for improving solid dosage form stability and performance.
    • Judicious selection of pH modifiers, concentrations, and manufacturing processes is crucial.
    • pH modulation effectively controls dissolution for both immediate and controlled-release formulations.