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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Structure and drug release in a crosslinked poly(ethylene oxide) hydrogel.

Boris Y Shekunov¹, Pratibhash Chattopadhyay, Henry H Y Tong

¹Ferro Pfanstiehl Laboratories, Pharmaceutical Technologies, Independence, Ohio 44131, USA. shekunovb@ferro.com

Journal of Pharmaceutical Sciences

|April 25, 2007

Summary

This study reveals how drug loading disorders poly(ethylene oxide) (PEO) hydrogels, impacting drug release. Lower polymer crystallinity leads to faster drug release, a key finding for controlled pharmaceutical polymer design.

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Published on: January 14, 2020

Area of Science:

Polymer Science
Materials Science
Pharmaceutical Technology

Background:

Hydrogels are advanced pharmaceutical polymers for controlled drug delivery.
Their macroscopic properties depend on structure and intermolecular interactions.
Poly(ethylene oxide) (PEO) hydrogels crosslinked by urethane bonds are promising drug delivery systems.

Purpose of the Study:

Investigate swelling, drug impregnation, and release mechanisms in PEO hydrogels.
Analyze the impact of drug loading on polymer matrix structure and crystallinity.
Correlate drug release profiles with hydrogel properties.

Main Methods:

Small-angle X-ray scattering (SAXS), Wide-angle X-ray scattering (WAXS), and Small-angle neutron scattering (SANS) were employed.
Phase transitions between lamellar and extended gel networks were determined.
Drug release kinetics were analyzed using a novel general cubic equation.

Main Results:

Drug loading (1-7% w/w acetaminophen, caffeine) induced significant disorder in the PEO matrix.
Acetaminophen showed a pronounced effect due to complex formation with PEO.
Drug release profiles were inversely correlated with polymer crystallinity, determining gel hydration velocity.

Conclusions:

Drug-induced structural disorder in PEO hydrogels influences drug release kinetics.
Polymer crystallinity is a critical factor controlling drug release rates.
The findings provide insights for designing effective sustained-release pharmaceutical polymer systems.