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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Immunological and central nervous system changes in mice suffering from Staphyloccocus aureus and treated with

I Ochigava1, L Kalandarishvili, M Zhvania

  • 1Pharmaceutical Company "Biopharm L", Tbilisi, Georgia. biopharml@yahoo.com

Folia Microbiologica
|April 26, 2007
PubMed

Insights

Live Saccharomyces cerevisiae var. vini cells stimulated the immune system and altered macroglial cells in the hippocampus of mice infected with Staphylococcus aureus.

Area of Science:

  • Microbiology
  • Immunology
  • Neuroscience

Background:

  • Staphylococcus aureus infections can impact both the immune and nervous systems.
  • Understanding the host-pathogen interaction is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To investigate the influence of Saccharomyces cerevisiae var. vini on Staphylococcus aureus-induced changes in the mouse immune and nervous systems.
  • To assess the effects of S. cerevisiae var. vini on antibacterial/antitoxic antibodies and hippocampal cell populations.

Main Methods:

  • Mice were exposed to Staphylococcus aureus.
  • The effects on immune markers (antibodies) and nervous system cells (neurons, macroglial cells) in the hippocampus were analyzed.
  • The impact of Saccharomyces cerevisiae var. vini treatment on these changes was evaluated.

Main Results:

  • Staphylococcus aureus infection affected antibacterial and antitoxic antibody levels.
  • S. aureus also altered the number of neurons and macroglial cells in specific hippocampal regions.
  • Treatment with Saccharomyces cerevisiae var. vini demonstrated immune stimulation.
  • Specifically, S. cerevisiae var. vini altered the total number of macroglial elements in the CA1 field of the hippocampus.

Conclusions:

  • Saccharomyces cerevisiae var. vini exhibits immunomodulatory properties.
  • The yeast can influence the nervous system's response during Staphylococcus aureus infection, particularly affecting macroglial cells in the hippocampus.

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