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Updated: Jul 15, 2026

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
Published on: June 30, 2023
Exploring the intermembrane space
1Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA. maly@chem.washington.edu
Abstract:
Despite the importance that many components of the intermembrane space (IMS) of mitochondria play in cellular function, the targeting sequences that are responsible for transporting proteins to this subcellular compartment are not fully understood. A recent study has identified a minimized protein sequence that is sufficient for localizing the apoptogenic protein Smac/DIABLO in the IMS. This newly identified targeting sequence is capable of directing other proteins to this submitochondrial compartment as well.
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