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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Infectious complications following unrelated cord blood transplantation

J-A van Burik1, C G Brunstein

  • 1Division of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. vanbu004@umn.edu

Vox Sanguinis
|April 26, 2007
PubMed
Abstract

Insights

Infections after cord blood transplantation occur in 30-40% of recipients, with bacterial infections common before engraftment and viral infections linked to graft-versus-host disease. The risk of serious infection is comparable to marrow transplants in children.

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Infections post-cord blood transplantation are not well-defined.
  • This review focuses on infections at death, their epidemiology, and stem cell source impact.

Purpose of the Study:

  • To outline infections at death following cord blood transplantation.
  • To review the epidemiology of individual infections.
  • To assess the impact of stem cell source on infection rates.

Main Methods:

  • Systematic review of studies published since 2000.
  • Analysis of registry data on cord blood transplantation outcomes.

Main Results:

  • Infection at death occurs in 30-40% of cord blood recipients.
  • Bacterial infections are common before engraftment; viral infections increase with graft-versus-host disease.
  • In children, UCB graft infection risk is similar to marrow and lower than T-cell-depleted sources. In adults, UCB transplantation shows higher serious infection rates than unrelated donor grafts, but similar survival outcomes.

Conclusions:

  • Further research is required to confirm findings.
  • The risk of infection for cord blood recipients needs direct comparison with unmanipulated marrow recipients.

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