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Related Experiment Videos

Discrete pigmentation after chemotherapy.

R Singal1, W W Tunnessen, J M Wiley

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Pediatric Dermatology
|September 11, 1991
PubMed
Summary
This summary is machine-generated.

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Chemotherapy can cause skin hyperpigmentation under occlusive dressings. This occurs when drugs like thiotepa are excreted in sweat, leading to toxic effects on skin cells. Minimizing sweat accumulation may prevent this side effect.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Bone marrow ablation is a critical step in certain cancer treatments.
  • Chemotherapy regimens like cyclophosphamide, etoposide, and carboplatin are used for bone marrow ablation.
  • Autologous bone marrow transplantation follows ablation to restore hematopoietic function.

Observation:

  • Two children with metastatic sarcoma developed discrete cutaneous hyperpigmentation after chemotherapy and bone marrow ablation.
  • Hyperpigmentation was localized to areas covered by tape, ECG pads, or elastic bandages.
  • Similar findings were observed in five adult women treated with intravenous thiotepa and cyclophosphamide.

Findings:

  • Thiotepa was detected in serum, skin, sweat, and gauze from affected patients.

Related Experiment Videos

  • The study suggests drug excretion in sweat accumulates under occlusive dressings.
  • This accumulation likely causes a toxic effect on epidermal or melanocyte cells, resulting in abnormal pigmentation.

    • Implications:

    • The findings suggest a mechanism for drug-induced patterned hyperpigmentation.
    • This complication may be linked to specific chemotherapy agents and occlusive dressings.
    • Minimizing sweat accumulation under occluded skin areas could prevent this adverse dermatologic effect.