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Updated: Jul 15, 2026
14:32
Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Sirtuin functions in health and disease
Hiroyasu Yamamoto1, Kristina Schoonjans, Johan Auwerx
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 Rue Laurent Fries, Boite Postale 10142, 67404 Illkirch, France.
Molecular Endocrinology (Baltimore, Md.)
|April 26, 2007
Summary
Sirtuins are NAD-dependent enzymes involved in crucial cellular functions like gene silencing and energy balance. Their diverse roles suggest potential as therapeutic targets for metabolic, neurodegenerative, and proliferative diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Sirtuins (silent information regulator 2-related enzymes) are NAD-dependent enzymes with deacetylase and ADP-ribosyltransferase activities.
- These enzymes are highly conserved across evolution, from bacteria to eukaryotes.
- Mammalian sirtuins (SIRT1-SIRT7) regulate diverse cellular processes including gene silencing, cell cycle control, apoptosis, and energy homeostasis.
Purpose of the Study:
- To review recent data on sirtuins.
- To discuss their mechanisms of action and biological roles.
- To explore their association with age-related human diseases.
Main Methods:
- Literature review of recent scientific data on sirtuins.
- Analysis of sirtuin functions in cellular and organismal models.
- Discussion of sirtuin involvement in human diseases.
Main Results:
- Sirtuins exhibit diverse enzymatic activities, including deacetylation and ADP-ribosylation.
- They play critical roles in fundamental cellular processes.
- Evidence links sirtuins to various age-related conditions.
Conclusions:
- Sirtuins are key regulators of cellular functions with broad biological implications.
- Their multifaceted roles position them as potential therapeutic targets for metabolic, neurodegenerative, and proliferative diseases.
- Further research into sirtuins may yield novel strategies for combating age-related human diseases.
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