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Cherubism in siblings: A case report.

D Sarda¹, P Kothari, B Kulkarni

¹Department of Pediatric Surgery, Lokmanya Tilak Muncipal General Hospital, Sion, Mumbai, Maharashatra, India.

Journal of the Indian Society of Pedodontics and Preventive Dentistry

|April 26, 2007

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Cherubism, a rare benign bone disease, causes jaw swelling and a cherubic facial appearance. This report details two siblings with cherubism, highlighting its familial occurrence and reviewing the condition.

Area of Science:

Oral and Maxillofacial Pathology
Pediatric Dentistry
Genetics

Background:

Cherubism is a rare, benign fibro-osseous condition affecting the jawbones.
It presents with characteristic facial swelling, leading to a 'cherubic' appearance.
Radiographic findings typically show bilateral, multilocular radiolucent lesions in the jaws.

Observation:

This case report focuses on cherubism occurring in two siblings.
The clinical and radiographic features observed in the siblings are detailed.
Histopathological examination reveals characteristic multinucleated giant cells within a fibrous connective tissue background.

Findings:

The presentation in siblings suggests a potential genetic component or familial predisposition.

Related Experiment Videos

The observed lesions align with the typical radiographic and histopathological descriptions of cherubism.

This familial occurrence adds to the understanding of cherubism's varied presentation.

Implications:

Early diagnosis and management are crucial for affected individuals.
Understanding familial patterns aids in genetic counseling and risk assessment.
Further research into the genetic basis of cherubism is warranted to improve therapeutic strategies.