Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The GBV-C envelope glycoprotein E2 does not interact specifically with CD81.

Thomas M Kaufman1, James H McLinden, Jinhua Xiang

  • 1Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, USA.

AIDS (London, England)
|April 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pitavastatin effects on lipids in relation to major adverse cardiovascular events: a REPRIEVE secondary analysis.

The lancet. HIV·2026
Same author

Elevated m<sup>6</sup>A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.

BMC cancer·2026
Same author

Time for a New Yellow Fever Vaccine.

The Journal of infectious diseases·2026
Same author

Viral Co-infection in COVID-19: Prevalence and Clinical Associations of Human Pegivirus.

medRxiv : the preprint server for health sciences·2026
Same author

Elevated m 6 A RNA Modifications Associate with Immune Dysregulation and Cancer in People with HIV-1.

Research square·2026
Same author

The hidden threat: HBV reactivation in the era of antiretroviral therapy optimization.

AIDS (London, England)·2026

GB virus C E2 protein inhibits HIV replication, but does not interact with the CD81 receptor as previously suggested. This finding clarifies the mechanism of GBV-C

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • GB virus C (GBV-C) E2 protein demonstrates in vitro inhibition of HIV replication.
  • Previous indirect evidence suggested CD81 as the cellular receptor for GBV-C E2 protein.

Purpose of the Study:

  • To investigate the interaction between GBV-C E2 protein and the CD81 receptor.
  • To determine if CD81 is the cellular receptor mediating the antiviral effects of GBV-C E2.

Main Methods:

  • Assessing GBV-C E2 protein binding to cells.
  • Evaluating the dependence of E2 binding on human CD81 expression.
  • Testing the competitive binding of soluble CD81 with GBV-C E2 for cell surface receptors.

Main Results:

Related Experiment Videos

  • GBV-C E2 protein binding to cells was independent of human CD81.
  • Soluble CD81 did not inhibit or compete with GBV-C E2 binding to cells.

    • Conclusions:

    • GBV-C E2 protein does not appear to interact with CD81.
    • The cellular receptor for GBV-C E2 remains to be identified, and the mechanism of HIV inhibition requires further investigation.