An introduction into proteomics and its clinical applications.
1Department of Pharmacology and Physiology, Mutah University, Mutah, Karak 61710, Jordan. Dr.ahram@gmail.com
Saudi Medical Journal
|April 26, 2007
Summary
Proteomics, the study of proteins, is vital in the post-genomic era for discovering disease biomarkers. New biotechnologies enhance protein analysis for improved disease detection and treatment strategies.
Area of Science:
- Biotechnology
- Proteomics
- Genomics
Background:
- The post-genomic era necessitates advanced techniques beyond DNA and RNA analysis.
- Proteomics offers a crucial approach to understanding protein expression, function, interaction, and structure.
Purpose of the Study:
- To review proteomic biotechnologies and their clinical applications.
- To highlight the role of proteomics in discovering protein biomarkers for disease detection, prognostication, and treatment.
Main Methods:
- 2-dimensional polyacrylamide gel electrophoresis
- Mass spectrometry
- Surface-enhanced laser desorption ionization mass spectrometry
- Protein microarrays
Main Results:
- These proteomic tools have been successfully applied to analyze biological samples.
- Biomarker discovery in human and other biological systems has been advanced through these techniques.
Conclusions:
- Advancements in proteomics are continuously expanding our knowledge of human biological systems.
- Proteomic technologies are essential for biomarker discovery and clinical applications.
Related Concept Videos
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Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
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01:33Peptide Identification Using Tandem Mass Spectrometry
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01:25Rapid Identification of Pathogens
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