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Nephrotic syndrome preceding psoriasis in children
Arvind Bagga1, Shina Menon, Pankaj Hari
1Division of Nephrology, Department of Paediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. arvindbagga@hotmail.com
Pediatric Nephrology (Berlin, Germany)
|April 26, 2007
Summary
Nephrotic syndrome can occur in children with psoriasis, sometimes years before skin symptoms appear. Treatment with steroids and cyclosporine effectively managed both kidney and skin conditions in these cases.
Area of Science:
- Pediatric Nephrology
- Dermatology
- Immunology
Background:
- Nephrotic syndrome is typically a late complication of psoriasis in adults, often presenting as IgA nephropathy or focal segmental glomerulosclerosis.
- The association between pediatric psoriasis and nephrotic syndrome, particularly minimal change disease, is not well-established.
Observation:
- This report details four pediatric cases where steroid-resistant nephrotic syndrome either preceded or coincided with psoriasis onset.
- Renal biopsies revealed minimal change disease in all affected children.
Findings:
- Therapeutic intervention with corticosteroids and cyclosporine led to remission of both nephrotic syndrome and psoriasis symptoms.
- The study suggests a potential shared pathogenesis involving cell-mediated immunity between minimal change nephrotic syndrome and psoriasis.
Implications:
- These findings highlight the importance of considering nephrotic syndrome in children presenting with psoriasis, even with atypical timing.
- Further research into the immunological links between these conditions could reveal novel therapeutic targets.
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