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[Granular cell laryngeal tumor].

C J Martínez Martínez1, L Fogué Calvo

  • 1Servicio de Anatomía Patológica, Hospital Ramón y Cajal, Madrid.

Revista Clinica Espanola
|September 1, 1991
PubMed
Summary

Granular cell tumors (GCTs) in the larynx typically affect vocal cords, causing hoarseness. Despite the name "myoblastoma," GCTs originate from Schwann cells and are usually benign, curable with surgery.

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Area of Science:

  • Otolaryngology
  • Pathology
  • Oncology

Background:

  • Granular cell tumors (GCTs) are rare neoplasms.
  • Laryngeal GCTs characteristically impact the vocal cords.
  • Dysphonia is the primary clinical symptom of laryngeal GCTs.

Observation:

  • The term "granular cell myoblastoma" is historically used but inaccurate.
  • Evidence strongly suggests GCTs originate from Schwann cells, not muscle cells.
  • While malignant variants exist, most GCTs exhibit benign behavior.

Findings:

  • Laryngeal GCTs predominantly affect vocal cords, leading to hoarseness.
  • The cellular origin of GCTs is confirmed as Schwann cells.
  • Complete surgical excision is curative for the vast majority of benign GCTs.

Implications:

  • Accurate terminology (GCT) is crucial for understanding tumor origin.
  • Early diagnosis and surgical intervention ensure favorable outcomes for laryngeal GCTs.
  • Further research into rare malignant GCTs may refine treatment strategies.

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