Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNAzymes as potential therapeutic molecules.

Yoshitaka Isaka1

  • 1Osaka University Graduate School of Medicine, Department of Advanced Technology for Transplantation, Suita 565-0871, Osaka, Japan. isaka@att.med.osaka-u.ac.jp

Current Opinion in Molecular Therapeutics
|April 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with loss of renal function in patients with polycystic kidney disease: a nationwide real-world data analysis.

Scientific reports·2026
Same author

Is phosphate burden an under-recognized driver of apparent treatment-resistant hypertension in CKD?

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same author

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Non-invasive quantitative assessment of kidney injury using near-infrared autofluorescence imaging.

Kidney international·2026
Same author

B-type natriuretic peptide level reduction and its predictors following sodium-glucose cotransporter 2 inhibitor treatment in patients with diabetic kidney disease: a Japan Chronic Kidney Disease Database Extension analysis.

Diabetes research and clinical practice·2026
Same author

Evaluation of the Association between Age, Sex and d-Amino Acid-Based Estimation of Glomerular Filtration Rate.

Clinical journal of the American Society of Nephrology : CJASN·2026

DNAzymes, a type of DNA-based therapeutic, offer a safer approach to controlling diseases by targeting specific messenger RNAs (mRNAs). This review explores their design, stability, and potential as novel drugs and biomarkers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • DNA-based biopharmaceuticals are emerging as potent therapeutics for gene regulation.
  • Existing DNA therapeutics include plasmids, antisense oligonucleotides, aptamers, ribozymes, DNAzymes, and short interfering RNAs.
  • DNAzymes offer sequence-specific RNA cleavage, presenting a potential therapeutic advantage.

Purpose of the Study:

  • To review the structural design and modification strategies for enhancing DNAzyme stability.
  • To discuss the therapeutic applications of DNAzymes in targeting pathogenic mRNAs.
  • To explore the potential of DNAzymes as biomarkers.

Main Methods:

  • Literature review of DNAzyme research.
  • Analysis of structural modifications for improved stability.

Related Experiment Videos

  • Evaluation of therapeutic strategies targeting specific mRNAs.
  • Assessment of DNAzyme utility as biomarkers.

    • Main Results:

    • DNAzymes can be structurally designed and modified for enhanced stability.
    • Sequence-specific cleavage of target RNAs by DNAzymes is a key mechanism.
    • DNAzymes show promise for developing safer therapeutic agents.
    • Potential applications as biomarkers are being investigated.

    Conclusions:

    • DNAzymes represent a promising class of DNA-based therapeutics.
    • Further research into structural design and modification can optimize their stability and efficacy.
    • DNAzymes hold potential for both therapeutic intervention and diagnostic applications.