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Related Experiment Videos

Using aptamers to identify and enter cells.

Ted Chu1, Jessica Ebright, Andrew D Ellington

  • 1University of Texas at Austin, Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, Austin, TX 78712, USA.

Current Opinion in Molecular Therapeutics
|April 27, 2007
PubMed
Summary
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Aptamers, which are nucleic acid-based binders, can now be selected against complex targets like cell surfaces. This advance enables the development of new diagnostics and drug delivery strategies for diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Nucleic acid aptamers are increasingly selected against protein targets.
  • Selection against complex targets like cell surfaces is becoming feasible.
  • Aptamers offer specific targeting capabilities.

Purpose of the Study:

  • To highlight the feasibility of selecting aptamers against complex targets, specifically cell surfaces.
  • To underscore the implications of anti-cell aptamer generation.

Main Methods:

  • Selection of aptamers against specific cell-surface antigens and cell types.
  • Generation of aptamers targeting tumor biomarkers and tumor cells.

Main Results:

  • Aptamers have been successfully generated to target specific cell types.

Related Experiment Videos

  • These aptamers can identify and bind to tumor biomarkers and tumor cells.

    • Conclusions:

    • The development of anti-cell aptamers is a significant advancement.
    • Anti-cell aptamers have critical implications for biomarker discovery, diagnostics, and drug delivery.