Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxia, gene expression, and metastasis.

Denise A Chan1, Amato J Giaccia

  • 1Department of Radiation Oncology, Division of Cancer and Radiation Biology, Stanford University School of Medicine, Stanford, CA 94305-5152, USA.

Cancer Metastasis Reviews
|April 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tirapazamine sensitises hypoxic homologous recombination-proficient NSCLC to PARP inhibition.

Cell death discovery·2026
Same author

FLASH radiotherapy enables dose escalation resulting in improved survival in an orthotopic muscle-invasive bladder cancer mouse model.

The British journal of radiology·2026
Same author

High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing.

Structure (London, England : 1993)·2025
Same author

Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect.

Cell death & disease·2025
Same author

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5.

Science advances·2025
Same author

Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect.

bioRxiv : the preprint server for biology·2025

Hypoxia, or low oxygen, in tumors increases cancer's resistance to treatments and promotes its spread. This review details how hypoxia activates genes that drive tumor invasion and metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Hypoxia is a common feature in solid tumors.
  • Tumor hypoxia is linked to poor prognosis and treatment resistance.
  • Hypoxia influences tumor cell behavior, including invasion and metastasis.

Purpose of the Study:

  • To review the role of hypoxia in cancer metastasis.
  • To highlight hypoxia-induced genes that promote tumor aggressiveness.
  • To discuss recent findings on metastasis mechanisms under hypoxia.

Main Methods:

  • Literature review of studies on hypoxia and cancer metastasis.
  • Analysis of gene expression changes induced by hypoxic conditions.
  • Focus on key metastatic steps: extracellular matrix interaction, migration, and proliferation.

Related Experiment Videos

Main Results:

  • Hypoxia significantly enhances tumor resistance to chemotherapy and radiation.
  • Hypoxia upregulates specific genes critical for tumor invasion and metastasis.
  • Identified genes play key roles in extracellular matrix degradation, cell migration, and proliferation.

Conclusions:

  • Hypoxia is a critical factor driving cancer metastasis.
  • Targeting hypoxia-mediated gene expression may offer new therapeutic strategies.
  • Understanding these mechanisms is crucial for improving cancer treatment outcomes.